Nucleation and motion of kink pairs on partial dislocations are examined by elasticity theory for materials with a high Peierls stress. Two approaches are used: one considers the change in average stacking-fault energy due to alloying elements and the other considers the change in local SFE due to a nearby solute atom. Both approaches highlight the role of SFE on kink nucleation, propagation and annihilation and both furnish strain rate as a function of stress, temperature and SFE. Model predictions are (...) compared with yield stress data for two systems: firstly, an intermetallic, MoSi 2 , which softens for alloying elements that decrease the SFE and hardens for Re additions that increase the SFE; secondly, a ceramic oxide, MgO-Al 2 O 3 spinel, which softens with increasing addition of excess alumina and at the same time exhibits a decrease in SFE. The average SFE approach agrees qualitatively with the data while quantitative agreement is obtained with the local SFE approach. The possibility is considered that the model applies to other materials, such as TiAl, HfV 2 and Fe 3 Al, which show softening with certain alloying additions. One requirement is that the dislocations are dissociated more than a few atomic distances; otherwise kink nucleation occurs on the perfect dislocation . Hence the model does not apply to materials such as bcc metals which only have a core dissociation. Normal hardening effects of solutes from size and modulus misfits are additive with any softening effects from a decrease in SFE and so may mask the latter, as occurs for W additions to MoSi 2. (shrink)

Deep brain stimulation — a novel surgical procedure — is emerging as a treatment of last resort for people diagnosed with neuropsychiatric disorders such as severe obsessive-compulsive disorder. The US Food and Drug Administration granted a so-called humanitarian device exemption to allow patients to access this intervention, thereby removing the requirement for a clinical trial of the appropriate size and statistical power. Bypassing the rigors of such trials puts patients at risk, limits opportunities for scientific discovery, and gives device manufacturers (...) unique marketing opportunities. We argue that Congress and federal regulators should revisit the humanitarian device exemption to ensure that it is not used to sidestep careful research that can offer valuable data with appropriate patient safeguards. (shrink)

Using covariant derivatives and the operator definitions of quantum mechanics, gauge invariant Proca and Lehnert equations are derived and the Lorenz condition is eliminated in U(1) invariant electrodynamics. It is shown that the structure of the gauge invariant Lehnert equation is the same in an O(3) invariant theory of electrodynamics.

In contemporary discussion of the philosophy of religion, or for that matter of any branch of philosophy, the names of Whitehead and Wittgenstein are not often linked. Whitehead's later work is, for the most part, treated as a rather specialized interest, an attractively under-cultivated field for the enterprising thesis-writer perhaps, but well away from the main centres of current philosophical activity. And what he has to say about specifically religious or theological issues 1 becomes simply one ramification of an ingenious (...) but somewhat eccentric system. Nonetheless, there is at least this much justification for considering it in relation to the much more influential and widely discussed views of Wittgenstein. Whitehead has some original things to say about God, Wittgenstein some original reasons for thinking that Whitehead's brand of originality is here radically misplaced. And the possibility or otherwise of such theological originality is an issue of very considerable importance for the philosophy of religion. (shrink)

Brodtkorb's "phenomenological reading" discusses the conceptually resistant realities, "World," "Body," "Others," and "Time," as they are interpreted in Moby Dick, and are focused by Melville in the inscrutable meaning of the white whale. "Mediation" is the key to interpretation, and, thus, the hero of the novel is Ishmael, who understands that the whale's meaning is constituted anew by each perceiver; Ishmael's mental life is a succession of attitudes—a series of "incantations"—which matches existence as process. From this phenomenological point of view, (...) Ahab's rigid interpretation of the whale as an allegory of divine malevolence is doomed, since allegory is a static mediated category, untrue to process. Yet this processional epistemology is itself in doubt if, as Brodtkorb admits, the uncertainty of the inscrutable is itself in question; and this doubt allows for the potential correctness of even Ahab's reductive allegorization. Thus, while Brodtkorb's phenomenology is a very sensitive instrument for indicating the shifting meanings of Melville's world, the final relation of potentially correct and incantatory concepts to this world is weakly conceived, due to the weakness of the instrument itself.—E. S. T. (shrink)

The introductory revised essay, "Horses of Wrath: Recent Critical Lessons," followed by nine reprinted essays, pits the Christian Rationalist, Wimsatt, an aroused Horse of Instruction, against the Tigers of Wrath, Blakean Myth critics led by Northrop Frye. Their battleground is the relation of poetry to life: what for the Blakeans is the fearful symmetry of poetry as the apocalypse of life is for Wimsatt the hateful siege of contraries, both an anarchy of life and a confusion of poetic limits. Wimsatt (...) supports the classical and Christian notion that harmony comes "in spite of" the conflict of good and evil, not "because of" that conflict, as the Blakeans would claim. For Wimsatt, poetry's unique kind of cognition is the analogous perspective it establishes toward contraries, namely the perspective of drama and metaphor in which is created a mock substance of the human condition. But after Wimsatt's analysis, we are left with a dualism which can be itself a hateful contrary: the more poetry performs its perspective function, the more it destroys its subject matter. It is also to the credit of Wimsatt's theoretic hesitancy that he will not let us forget these contraries.—E. S. T. (shrink)

Brodtkorb's "phenomenological reading" discusses the conceptually resistant realities, "World," "Body," "Others," and "Time," as they are interpreted in Moby Dick, and are focused by Melville in the inscrutable meaning of the white whale. "Mediation" is the key to interpretation, and, thus, the hero of the novel is Ishmael, who understands that the whale's meaning is constituted anew by each perceiver; Ishmael's mental life is a succession of attitudes—a series of "incantations"—which matches existence as process. From this phenomenological point of view, (...) Ahab's rigid interpretation of the whale as an allegory of divine malevolence is doomed, since allegory is a static mediated category, untrue to process. Yet this processional epistemology is itself in doubt if, as Brodtkorb admits, the uncertainty of the inscrutable is itself in question; and this doubt allows for the potential correctness of even Ahab's reductive allegorization. Thus, while Brodtkorb's phenomenology is a very sensitive instrument for indicating the shifting meanings of Melville's world, the final relation of potentially correct and incantatory concepts to this world is weakly conceived, due to the weakness of the instrument itself.—E. S. T. (shrink)

One of the most important theoretical and ideological tasks of Marxist philosophy is the critical study of the philosophical thought of the West. In the second half of the 1970s and beginning of the 1980s, the ideological struggle on the international arena entered a new stage. It was characterized by the turn of the forces of imperialist reaction away from the politics of detente to the politics of the "cold war," to the active opposition to the forces of peace, democracy, (...) and socialism. The struggle of ideas has swung back and forth in the context of, on the one hand, a resurgence of reactionary anticommunist tendencies, and the stimulation and expansion of antimilitary movements and the struggles of the peoples for peace and socialism on the other. (shrink)

Warning research participants and patients about potential risks associated with participation/treatment is a fundamental part of consent. However, such risk warnings might cause negative expectations and subsequent nocebo effects (i.e., negative expectations cause negative outcomes) in participants. Because no existing review documents how past research has quantitatively examined nocebo effects – and negative expectations – arising from consent risk warnings, we conducted a pre-registered scoping review (N = 9). We identified several methodological issues across these studies, which in addition to (...) mixed findings, limit conclusions about whether risk warnings cause nocebo effects. (shrink)

PURPOSE:To report the localization of a gene causing drusen and macular degeneration in a previously undescribed North American family. METHODS:Genetic mapping studies were performed using linkage analysis in a single family with drusen and atrophic macular degeneration. RESULTS:The clinical manifestations in this family ranged from fine macular drusen in asymptomatic middle-aged individuals to atrophic macular lesions in two children and two elderly patients. We mapped the gene to chromosome 6q14 between markers D6S2258 and D6S1644. CONCLUSIONS:In a family with autosomal dominant (...) drusen and atrophic macular degeneration, the gene maps to a 3.2-cM region on chromosome 6q14. This locus appears to be distinct from, but adjacent to, the loci for cone-rod dystrophy 7 (CORD7) and North Carolina macular dystrophy (MCDR1). Future identification of the gene responsible for the disease in this family will provide a better understanding of macular degeneration. (shrink)

The introductory revised essay, "Horses of Wrath: Recent Critical Lessons," followed by nine reprinted essays, pits the Christian Rationalist, Wimsatt, an aroused Horse of Instruction, against the Tigers of Wrath, Blakean Myth critics led by Northrop Frye. Their battleground is the relation of poetry to life: what for the Blakeans is the fearful symmetry of poetry as the apocalypse of life is for Wimsatt the hateful siege of contraries, both an anarchy of life and a confusion of poetic limits. Wimsatt (...) supports the classical and Christian notion that harmony comes "in spite of" the conflict of good and evil, not "because of" that conflict, as the Blakeans would claim. For Wimsatt, poetry's unique kind of cognition is the analogous perspective it establishes toward contraries, namely the perspective of drama and metaphor in which is created a mock substance of the human condition. But after Wimsatt's analysis, we are left with a dualism which can be itself a hateful contrary: the more poetry performs its perspective function, the more it destroys its subject matter. It is also to the credit of Wimsatt's theoretic hesitancy that he will not let us forget these contraries.—E. S. T. (shrink)

Solon's fragments 9–11 are preserved in three late authors: frr. 9 and 11 by Diodoros Sikelos , 9.20.2, Plutarch , Solon 3.6 and 30.3 respectively, and Diogenes Laertios , 1.50 and 1.51 respectively; and fr. 10 by Diogenes Laertios alone, 1.49. They are all quoted in the context of Solon's reaction to Peisistratos. Stories on this theme were circulating by the time of the Aristotelian Athenaion Politeia , and Rhodes' scepticism about them is well founded. Its author did not garnish (...) his version of events with these poems, nor indeed with any Solonian utterance, and he explicitly states that myth-making on this subject had already resulted in two stories about Solon and Peisistratos which were chronologically impossible. (shrink)

To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome 6B and (...) least on 6D. The 264 ESTs that detected orthologous loci on all three homoeologs using one restriction enzyme were used to construct a consensus physical map. The physical distribution of ESTs was uneven on chromosomes with a tendency toward higher densities in the distal halves of chromosome arms. About 43% of the wheat group 6 ESTs identified rice homologs upon comparisons of genome sequences. Fifty-eight percent of these ESTs were present on rice chromosome 2 and the remaining were on other rice chromosomes. Even within the group 6 bins, rice chromosomal blocks identified by 1-6 wheat ESTs were homologous to up to 11 rice chromosomes. These rice-block contigs were used to resolve the order of wheat ESTs within each bin. (shrink)

In recent years, we have seen a new concern with ethics training for research and development professionals. Although ethics training has become more common, the effectiveness of the training being provided is open to question. In the present effort, a new ethics training course was developed that stresses the importance of the strategies people apply to make sense of ethical problems. The effectiveness of this training was assessed in a sample of 59 doctoral students working in the biological and social (...) sciences using a pre–post design with follow-up and a series of ethical decision-making measures serving as the outcome variable. Results showed not only that this training led to sizable gains in ethical decision making but also that these gains were maintained over time. The implications of these findings for ethics training in the sciences are discussed. (shrink)

To properly understand behavior, we must obtain both ultimate and proximate explanations. Put briefly, ultimate explanations are concerned with why a behavior exists, and proximate explanations are concerned with how it works. These two types of explanation are complementary and the distinction is critical to evolutionary explanation. We are concerned that they have become conflated in some areas of the evolutionary literature on human behavior. This article brings attention to these issues. We focus on three specific areas: the evolution of (...) cooperation, transmitted culture, and epigenetics. We do this to avoid confusion and wasted effort—dangers that are particularly acute in interdisciplinary research. Throughout this article, we suggest ways in which misunderstanding may be avoided in the future. (shrink)

Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants’ locations, online activity, phone and text message usage, heart rate, sleep, physical activity, and more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate to guide researchers for when, if, and how to return this unprecedented number of potentially sensitive results about each participant’s real-world behavior. To address this gap, we convened an interdisciplinary expert working group, supported by (...) a National Institute of Mental Health grant. Building on established guidelines and the emerging norm of returning results in participant-centered research, we present a novel framework specific to the ethical, legal, and social implications of returning IRRs in digital phenotyping research. Our framework offers researchers, clinicians, and Institutional Review Boards (IRBs) urgently needed guidance, and the principles developed here in the context of psychiatry will be readily adaptable to other therapeutic areas. (shrink)

Understanding terrestrial carbon metabolism is critical because terrestrial ecosystems play a major role in the global carbon cycle. Furthermore, humans have severely disrupted the carbon cycle in ways that will alter the climate system and directly affect terrestrial metabolism. Changes in terrestrial metabolism may well be as important an indicator of global change as the changing temperature signal. Improving our understanding of the carbon cycle at various spatial and temporal scales will require the integration of multiple, complementary and independent methods (...) that are used by different research communities. Tools such as air sampling networks, inverse numerical methods, and satellite data allow us to study the strength and location of the global- and continental-scale carbon sources and sinks. Bottom-up studies provide estimates of carbon fluxes at finer spatial scales and examine the mechanisms that control fluxes at the ecosystem, landscape, and regional scales. Bottom-up approaches include comparative and process studies that provide the necessary mechanistic information to develop and validate terrestrial biospheric models. An iteration and reiteration of top-down and bottom-up approaches will be necessary to help constrain measurements at various scales. We propose a major international effort to coordinate and lead research programs of global scope of the carbon cycle. (shrink)

We consider the relation between versions of Ramsey’s Theorem and König’s Infinity Lemma, in the absence of the axiom of choice.